Two new studies show cost-effectiveness of dengue vaccination in Brazil

Hospitalizations due to dengue can be costly in Brazil, with $ 448 estimated medical costs per case.  And since each year, Brazil sees hundreds of thousands of hospitalized dengue cases in addition to even more cases treated at home, the total costs have serious implications on national health care budgets.  One study showed total annual costs due to dengue disease reaching an estimated $1.2 billion.

There may be relief on the horizon as vaccination can give a boost to other dengue prevention and control efforts in Brazil. In recent weeks, two new studies have modelled the cost-effectiveness of dengue vaccination in Brazil, estimating the investment value of implementing vaccination broadly across indicated populations.

Both studies show that vaccination is a good investment in Brazil, contributing to reduction of the disease burden.1,2  The studies further show that the value of the investment increases when vaccination covers more than just routine age populations (9 years old) and continues to grow the more age groups and coverage rates increase. One model showed that the combination of routine vaccination and large “catch-up” campaigns resulted in a greater reduction of dengue burden (by up to 93%) than routine vaccination alone.3

The dengue vaccine was approved and made available in Brazil in 2016, including use in a first state-level public program in Paraná State where roughly 55,000 annual dengue cases are reported.  The campaign has effectively rolled out two vaccine doses over six months (in September 2016 and March 2017), amongst thousands of residents.   Final dose of the three-course schedule will be provided in August and September of this year.


  1. Shim, Ehuna et al.  Cost-Effectiveness of Dengue Vaccination Programs in Brazil. Am J Trop Med Hyg. 2017 May 3; 96(5): 1227–1234.  doi:  10.4269/ajtmh.16-0810
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417221/
  2. Durand, Laure, et al. Cost-effectiveness of dengue vaccination in Brazil.  JBES 10.21115/JBES.v9.n1.p12-2
  3. Shim, Ehuna et al.  Cost-Effectiveness of Dengue Vaccination Programs in Brazil. Am J Trop Med Hyg. 2017 May 3; 96(5): 1227–1234.  doi:  10.4269/ajtmh.16-0810
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417221/