Dengue fever is a mosquito-borne disease caused by four dengue virus serotypes (1 to 4). Overall, the disease is a threat to about half of the world’s population and is a health priority in many countries of Latin America and Asia. Of the estimated 390 million people infected annually, 500,000, including children, develop dengue hemorrhagic fever (DHF), a severe form of the disease. DHF is a leading cause of hospitalization, placing tremendous pressure on strained medical resources and having a heavy economic and societal impact. Many factors have contributed to the re-emergence and dramatic increase in dengue fever including urbanization and increased travel which facilitate the dissemination of dengue viruses and the circulation of the disease. The World Health Organization (WHO) has set a target to reduce dengue mortality by 50% and morbidity by 25% by the year 2020.